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Clinical Pulmonary Infection Score (CPIS):
Am. J. Respir. Crit. Care Med., Volume 168, Number 2, July 2003, 173-179

The mean score for patients with confirmed VAP was 6.5 and for unconfirmed cases it was 5.9. However, the use of Gram stains of the BAL or the protected brush specimens notably improved the accuracy when incorporated into the CPIS score. Gram stains of the BAL were positive in 34 of 40 (85%) confirmed cases and in 10 of 39 (26%) unconfirmed cases. The results with Gram stain of the protected brush specimens were similar. Adding the Gram stain to the CPIS baseline increased the CPIS score to an average of 7.3 in confirmed cases compared with 6.4 in unconfirmed cases. The CPIS scoring system is summarized in Table 1

Clinical Pulmonary Infection Score (CPIS)
Tracheal secretions Rare Abundant Abundant and purulent
Chest x-ray No infiltrate Diffuse Focal infiltrate
Temp (°C) 36.0-38.4 38.5-38.9 < 36 or > 39
White blood cell count (x 1000/mm3) 4-11 < 4 or > 11 < 4 or > 11
+ band > 0.5
PA02/F102 mm Hg > 240 or ARDS < 240 + no ARDS
Microbiology Negative Positive
Reseults & Recommendation
Score
VAP Probability

  Sensitivity Specificity
Clinical estimate 50% 58%
CPIS score > 6* 60% 59%
BAL Gram stain 85% 74%
Telescoping catheter 60% 90%
CPIS + BAL Gram stain 85% 49%
CPIS + telescoping catheter 78% 36%

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